In such a context, our current study finds that stabilization of Vimentin proteins can be crucial for AKT/VAL-induced cancer cell adhesion, invasion, and survival, consequently resulting in local and distant metastasis of LAD cells, supporting the notion that abnormal levels of Vimentin may play pivotal biological roles at multiple levels in the complex process of LAD metastasis. Here, AKT1 is linked to leukocyte adhesion deficiency.