Moreover, while tumor cells in each of the xenografts formed by myr-AKT1-overexpressing LAD cells generated invasive fronts and irregularly invaded into the neighboring subcutaneous tissue, nearly all the tumor xenografts formed by vector-control cells or VAL-silenced myr-AKT1-overexpressing LAD cells presented clear tissue boundary; notably, silencing VAL failed to reverse the promoting effect of AKT1 on tumor cell growth (Fig. 3e and Supplementary Fig. 4b, c). Here, AKT1 is linked to neoplasm.