LINC01546 and neoplasm: Although VAL overexpression or knockdown failed to induce phenotypic and molecular changes of EMT (Supplementary Fig. 3a–f), LAD cells overexpressing VAL exhibited much stronger abilities to bind to and invade through the extracellular matrix, as well as to resist suspension-induced anoikis, which has been implicated to importantly contribute to tumor cell survival in the cascaded metastasis process27,28, as compared to vector-control cells (Fig. 2a–c).