We noticed that, compared with the IgG control group, anti-Notch1 or Avastin treatment reduced the tumor volume (Fig. 8b) and weight (Fig. 8c) by 20–60%, while strong inhibition of tumor growth was achieved by anti-Notch1 and Avastin combinatorial treatment, with over 80% antitumor efficacy. The gene discussed is NOTCH1; the disease is neoplasm.