In addition, analysis of established breast CSC markers and properties29 revealed strong decreases in the sphere-forming capacity (Fig. 2c), the CD44+CD24− breast CSC population (Fig. 2d) and the ALDH activity (Fig. 2e) in tumor cells from PyMT;Zeb1cKO mice compared to those from PyMT mice. This evidence concerns the gene LDHA and neoplasm.