Considering that VEGFA has been reported to enhance Jag1 expression in adventitial microvascular endothelial cells32, this raised the possibility that depletion of Zeb1 in tumor cells might disrupt VEGFA-dependent paracrine actions to impair Jag1 activity in endothelial cells and subvert a malignant perivascular niche. Here, ZEB1 is linked to neoplasm.