SQSTM1 and osteoporosis: Consistent with this findings, it was suggested that the secretion of LC3II/I, Unc-51 like kinase 1 (Ulk-1), and Beclin-1 was significantly reduced with aging, while the expression of SQSTM1/p62 (sequestosome 1) and osteocytic apoptosis were dramatically elevated, implying senile osteoporosis concomitant with bone loss might be attributed to weakening osteocytic autophagy, which is independent of apoptosis124 (Table 1).