TMPRSS2 and infection: Our evaluation of genetic influences on airway ACE2 and TMPRSS2 expression revealed a single eQTL for ACE2 and several common eQTL variants for TMPRSS2. While both the effect size and explanatory power of these variants paled in comparison to the influence of T2 inflammation and interferon signaling in multi-variable modeling of expression for these genes, the effect of these variants may still be significant enough to alter infection rates and/or illness severity, especially in the populations where these variants are most frequent.