In contrast, the TMPRSS2 eQTL variant associated with decreased expression, rs1475908, occurred across all world populations, with the highest allele frequencies among East Asians (AF = 38%), Europeans (AF = 35%), intermediate frequencies among Africans (AF = 26%) and Ashkenazi Jews (AF = 23%), and the lowest frequency among Latinos (AF = 17%). This evidence concerns the gene TMPRSS2 and atrial fibrillation.