For overall cancer, there was evidence of association for variants in the HMGCR gene region (odds ratio [OR] 1.32, 95% confidence interval [CI] 1.13–1.53, p=0.0003) but not for other gene regions: for PCSK9 (OR 1.03, 95% CI 0.92–1.14, p=0.66), for LDLR (OR 0.99, 95% CI 0.92–1.07, p=0.86), for NPC1L1 (OR 0.87, 95% CI 0.73–1.04, p=0.13), for APOC3 (OR 1.08, 95% CI 0.98–1.19, p=0.15), or for LPL (OR 1.03, 95% CI 0.95–1.13, p=0.45). This evidence concerns the gene NPC1L1 and cancer.