Other potential statin-mediated mechanisms of tumor suppression include the reduction of systemic inflammatory mediators like interleukin 1-beta and tumor necrosis factor (Park et al., 2008; Bruegel et al., 2006), and epigenetic regulation through inhibiting HMGCR-mediated deacetylation (Lin et al., 2008), which contributes to colorectal cancer in mouse models (Pisanti et al., 2014). This evidence concerns the gene TNF and colorectal cancer.