A limited number of Mendelian randomization studies have investigated the relationship between HMGCR inhibition and cancer (PRACTICAL consortium et al., 2016; Rodriguez-Broadbent et al., 2017; Orho-Melander et al., 2018; Nowak and Ärnlöv, 2018; Yarmolinsky et al., 2020), with protective associations observed for prostate cancer (PRACTICAL consortium et al., 2016), colorectal cancer (Rodriguez-Broadbent et al., 2017), breast cancer (Orho-Melander et al., 2018; Nowak and Ärnlöv, 2018), and ovarian cancer (Yarmolinsky et al., 2020). This evidence concerns the gene HMGCR and colorectal cancer.