In both EVs and plasma samples, MIP-1alpha and IP-10 were both elevated in the ME/CFS group but not statistically different, a trend previously observed in a report that considered disease severity and compared mild ME/CFS patients to controls [12] but opposite to another study showing significant lower levels of these cytokines in ME/CFS plasma samples [10]. This evidence concerns the gene CXCL10 and myalgic encephalomeyelitis/chronic fatigue syndrome.