Molecular abnormalities of AML include NPM1, CEBPα, RUNX1, DNMT3A, TET2, IDH1/2, FLT3, KIT, NRAS, WT1, TP53, PTPN11, U2AF1, SMC1A, SMC3, STAG2, RAD21, ASXL1/2, and EZH2, which are mutated in more than 5% of AML cases. Here, SMC1A is linked to acute myeloid leukemia.