In the present study, Axin2 expression was found in the cytoplasm of cancer cells in 168 (77.4%) patients with OSCC, and immunoreactivity against Axin2 was high in 101 (high-Axin2, 46.5%) OSCC tissue samples and low in 116 (low-Axin2, 53.5%). This evidence concerns the gene AXIN2 and cancer.