Both high Axin2 expression and high Snail expression showed a significant association with T stage (p < 0.001 and p = 0.031), lymph node metastasis (both p < 0.001), vascular invasion (p = 0.01 and p = 0.019), and bone invasion (p < 0.001 and p = 0.028) in the present study. This evidence concerns the gene AXIN2 and metastatic malignant neoplasm in the lymph nodes.