TIMP1 and pulpitis: By detecting the dental fluid in tooth cavities using polyvinylidene difluoride membrane, Brizuela et al. [18] found that the biomarkers of fibroblast growth factors acid (FGF-acid), interleukin-1α (IL-1α), IL-6, and tissue inhibitor of metalloproteinases 1 (TIMP-1) may collectively be useful for molecular diagnostics in pulpitis.