MPV and PDW were considered as indicators of platelet activation [17, 37], and previous studies reported that the aberrance of MPV and PDW levels may be correlated with megakaryocyte dysfunction, heterogeneous demarcation and abnormal bone marrow haematopoietic system [38], and the release of inflammatory cytokines, including interleukin-6 and several colony stimulating factors such as granulocyte colony stimulating factors, by tumour cells can regulate megakaryocytic maturation and subsequent platelet synthesis and size [39]. This evidence concerns the gene IL6 and neoplasm.