Increased PLT can promote CD40 ligand production and contribute to the inflammatory response [31], and the inflammatory response participates in tumourigenesis and tumour development through several aspects, such as the induction of reactive oxygen species and subsequent DNA damage, promotion of tumour cell growth and angiogenesis via the secretion of various cytokines and enhanced tumour cell adhesion, and the induction of potential tumour micrometastasis [32]. This evidence concerns the gene CD40LG and neoplasm.