Thirty-five regions affected by CNAs were found, which correspond to 2% of the genome, including amplifications on 12q13–15, which included known genes associated with DDLPS pathogenesis, such as DDIT3, CDK4, MDM2, YEATS4, and FRS [2, 4–6] (Figs. 2b & c; Table S3). Here, YEATS4 is linked to dedifferentiated liposarcoma.