IFNB1 and myeloid sarcoma: The protective role of IFN-β in MS, however, is puzzling in light of the well-established pathogenic role of type I IFN in other autoimmune diseases, such as systemic lupus erythematosus, Sjögren syndrome, and neuromyelitis optica, to name a few (Axtell et al., 2011; Crow, 2014).