IL21 and myeloid sarcoma: On the other hand, Nurr1 was shown to be upregulated in peripheral blood T cells of MS patients and to drive transcription of proinflammatory Il17, Ifng, and Il2 in mice with EAE (Doi et al., 2008); it also reportedly participates in Th17 cell maturation and controls their ability to produce IL-21 (Raveney et al., 2013).