We next isolated CD4+ T cells from spleens and dLNs of WT and GRIP1-cKO mice at day 7 postimmunization (DPI7) or DPI20, restimulated them with myelin oligodendrocyte glycoprotein (MOG) peptide in vitro for 72 h, and analyzed the production of Th1 and Th17 cytokines implicated in MS pathology as well as the EAE model. This evidence concerns the gene CD4 and myeloid sarcoma.