IL6 and Cachexia: For example, high serum proinflammatory cytokines including interleukin-6 (IL-6) and IL-6 family cytokines IL-11, LIF, and Oncostatin M associate with cachexia in Colon-26 (C-26) tumor-bearing female mice and IL-6/STAT3 activation in skeletal muscle induce both acute phase protein synthesis and skeletal muscle wasting [40].