ILK and breast cancer: Although mammary epithelial disruption of ILK had little impact on normal mammary gland development, loss of the ILK resulted in a significant inhibition of mammary tumor induction while inhibition of ILK function using an ILK inhibitor or siRNA-mediated silencing in ErbB2-expressing cell epithelium induced apoptosis and severely reduced cells’ in vitro invasive capacity [39].