In this study, MI rats and peritoneal macrophages were treated with Calhex231, CaSR agonist, autophagy agonist, and antagonist or the inhibitor of NLRP3 inflammasome in order to elucidate the role and molecular mechanism of Calhex231 in myocardial fibrosis post MI. This evidence concerns the gene NLRP3 and myocardial infarction.