In this study, echocardiographic indictors of cardiac dimensions and function, myocardial histological staining including HE staining and Masson staining, and myocardial fibrosis proteins markers in rats suggested that ventricular remodelling occurred after MI in rats, while the use of Calhex231, a specific CaSR inhibitor, could inhibit ventricular remodelling post MI in rats. Here, CASR is linked to Myocardial fibrosis.