Family studies, such as the report by Guttman‐Yassky et al39 of the IL6 promoter GC genotype and the HLA‐DRB1*11 allele in a familial clustering of classic KS, are thought to bypass this limitation although these are limited in population applicability and statistical power and also require validation. Here, HLA-DRB1 is linked to Kaposi's sarcoma.