A toll‐like receptor 4 (TLR4) SNP (NM_138554.5:c.896A>G, rs4986790) which results in decreased surface expression of TLR4, an important pattern recognition receptor in activation of the innate immune system, was associated with increased incidence of MCD in KSHV+ HIV‐1+ patients compared to non‐KSHV cancer controls and patients with KS63; this SNP was further linked to patients with African ancestry.87 Here, TLR4 is linked to cancer.