MBL2 haplotypes (based on combinations of two promoter region genotypes (−550 H/L and −221 Y/X) and a structural region genotype (exon 1 A/O)) associated with intermediate expression of MBL, an innate immune system protein, were found to be associated with lower CD4 count in HIV and KSHV co‐infected patients compared to patients with only HIV infection.47 This evidence concerns the gene MBL2 and HIV infectious disease.