Indeed, mutation analysis revealed two novel, non‐synonymous heterozygous variants (NM_004431.5:c.2099T>C and NM_004431.5:c.2835G>T) in the EPHA2 tyrosine kinase domain to be significantly associated with KS in a cohort of HIV‐infected South African patients stratified by KS status.58 This evidence concerns the gene EPHA2 and Kaposi's sarcoma.