Similarly, Goedert et al50 found HLA‐C group 1 (HLA‐C*01, *03, *07, *08) homozygosity to be protective against KSHV infection (see Section 3.1), but once infected to confer increased risk of KS development through a proposed mechanism of NK cell activation and induced inflammation. This evidence concerns the gene HLA-C and Kaposi's sarcoma.