For example, FX/FXa has been shown to interact directly with PAR-2 and indirectly with endothelial protein C receptor–dependent recruitment of PAR-1 and appears to play a protective role.123As the pathophysiology of COVID-19 is better understood and more tailored therapeutic approaches to anticoagulation are evaluated, it will be essential to ensure that the protective role of the coagulation pathway is not completely eliminated and that we do not cause adverse bleeding events. The gene discussed is F10; the disease is COVID-19.