Recently, the role of the vascular endothelium in the pathology of COVID-19 has been reported to potentially be a primary driver in the development of intravascular thrombosis and related sequelae.63, 64, 65, 66, 67Although it is beyond the scope of this article to discuss the very important and vast role of the endothelium in inflammation and coagulation, we do want to touch upon the potential role of FX in this paradigm (Fig. 2E). The gene discussed is F10; the disease is COVID-19.