New subsets of tumor-infiltrating lymphocytes (TILs) related to HCC have been identified, such as exhausted CD8+ T cells, exhausted Tregs, LAMP3+ dendritic cells (DCs), and tumor-associated macrophages (TAMs), gradually unraveling the immune landscape of hepatocellular carcinoma (7, 8). This evidence concerns the gene CD8A and hepatocellular carcinoma.