The transcription machinery of YAP1/TAZ and TEA domain transcription factor (TEAD) activates the transcription of CD44 by coupling to the CD44 promoter at TEAD binding sites, thereby encouraging the propagation of malignant pleural mesothelioma (MPM) cell lines (Tanaka et al., 2017). The gene discussed is CD44; the disease is malignant pleural mesothelioma.