MMP14 and cancer: In line with this, the dense extracellular matrix scaffold serves also as barrier and can be overcome in two different ways, one mechanical mode without the degradation of the extracellular matrix (Friedl et al., 2001; Wolf et al., 2003, 2007) and one enzymatic mode involving collagenolytic activity through MMPs, such as mainly MT1-MMP in the course of cancer invasion (Stetler-Stevenson and Yu, 2001; Itoh and Nagase, 2002; Hojilla et al., 2003; Cruz-Munoz et al., 2006).