miR-486 and miR-26a repressed the translation of PTEN in a model of CKD, resulting in enhanced phosphorylation of Akt and FoxO1; miR-486 and miR-26a also directly inhibit the translation of FoxO1, and both of these effects lead to suppression of Atrogin-1 and MuRF-1 to prevent muscle atrophy (Small et al., 2010; Xu et al., 2012; Wang B. et al., 2019). Here, AKT1 is linked to chronic kidney disease.