PTEN and chronic kidney disease: Overexpression of miR-23a/miR-27a in CKD mice enhanced grip strength, decreased muscle loss, increased the phosphorylation of Akt and FoxO1, decreased the activation of PTEN and FoxO1, and reduced Atrogin-1 and MuRF-1 protein levels, preventing muscle wasting via PTEN/PI3K/Akt signaling (Wang B. et al., 2017).