miR-206 enhances wasting by decreasing the action of eIF4E3, and miR-21 inhibits the expression of transcription factor YY1 and eIF4E3, thus promoting muscle wasting in four different models: starvation, denervation, diabetes, and cancer cachexia induced by colon carcinoma (Soares et al., 2014). This evidence concerns the gene EIF4E3 and diabetes mellitus.