In mammalian cells, Klhl21 is thought to be involved in E3-ubiquitination during cytokinesis and regulation of cortical dynamics (Maerki et al., 2009; Courtheoux et al., 2016) and is implicated in diverse types of carcinoma (Shi et al., 2016; Chen et al., 2018). This evidence concerns the gene KLHL21 and carcinoma.