TNF and rheumatoid arthritis: According to quantification of lncRNA NEAT1, miR-23a/MDM2/SIRT6 and the extent of p65 phosphorylation, lncRNA NEAT1, MDM2 and the extent of p65 phosphorylation were significantly upregulated while miR-23a and SIRT6 expression was diminished in FLSs from RA mice (Figures 6A,B), accompanied by promoted cell viability and secretion of inflammatory factors (IL-6, IL-1β, and TNF-α) (Figures 6C,D).