Ki67 expression by immunohistochemistry and secretion of inflammatory factors (IL-6, IL-1β, and TNF-α) by ELISA revealed that Ki67 level in mouse synovial tissues and secretion of inflammatory factors (IL-6, IL-1β, and TNF-α) in mouse serum were both potentiated in the presence of PBMC-derived exos from RA patients while further delivery of shNEAT1 significantly reversed the results (Figures 8C,D). This evidence concerns the gene TNF and rheumatoid arthritis.