To further verify the action of lncRNA NEAT1 in RA, control mice were used and injected with PBMC-derived exos from RA patients, which induced higher levels of lncRNA NEAT1, MDM2 and p-p65 in synovial tissues where miR-23a and SIRT6 levels were reduced. The gene discussed is SIRT6; the disease is rheumatoid arthritis.