In order to determine the role of lncRNA NEAT1 in RA in vivo, we injected PBMC-derived exos in mice on the 1st, 3rd, and 5th days (Wiklander et al., 2015) and then determined the expression of lncRNA NEAT1 and miR-23a/MDM2/SIRT6, and phosphorylation of p65 in mouse synovial tissues. Here, MDM2 is linked to rheumatoid arthritis.