Additionally, Andrographolide (ANDRO) one of the main constituents of the medicinal plant Andrographis paniculata (Panossian et al., 2000; Cheung et al., 2001), that inhibits GSK-3β through a substrate-competitive mode of action (Tapia-Rojas et al., 2015), promoted hippocampal neurogenesis in the APPswe/PSEN1ΔE9 mouse model of AD (Varela-Nallar et al., 2015). The gene discussed is GSK3B; the disease is Alzheimer disease.