lncRNA LET is considered a tumor suppressor in a variety of cancer types which also accounts for RCC, where LET was shown to enhance apoptosis and impair mitochondrial membrane potential by targeting miR-373-3p, thereby regulating Dickkopf 1 and tissue TIMP2 expression (Weidle et al., 2017; Ye et al., 2019). This evidence concerns the gene TIMP2 and renal cell carcinoma.