SPI1 and cancer: In the results from the pathview analysis of pathways in cancer, the expression of a series of genes was disturbed by stimulation with F. nucleatum; for instance, the levels of SDF1, Jak, HGF, IL-6, AML-ETO, HIF-α, and MITF were upregulated, while those of Ras, FGFR, MSK1, RXR, PU.1, TGFβ, and GLI1 were downregulated, and the expression of many other genes was significantly changed during the infection progress (Figure 6).