LIF and idiopathic pulmonary fibrosis: In a recent study, it was reported that the first line antidiabetic and metabolic drug metformin, acting as a AMPK-activator, was capable to enhance the activated MYF to LIF transition both (1) in vitro in primary fibroblasts from IPF patients, (2) ex vivo in precision cut lung slices from end-stage IPF lungs obtained from transplant patients, and (3) in vivo using bleomycin-induced fibrosis mouse models in the context of lineage tracing of activated MYF during resolution (Kheirollahi et al., 2019).