High glycemic load diet can lead to the rise in blood glucose in the body, therefore, islets secrete large amounts of insulin to lower blood glucose, and elevated insulin levels lead to increased secretion of insulin-like growth factors-1 (IGF-1), IGF-1 can increase androgen levels, promote sebum secretion, and promote hyperkeratosis of hair follicle sebaceous glands to affect lipid excretion, thereby inducing or aggravating the occurrence of acne (53–56). The gene discussed is INS; the disease is Hyperkeratosis.