NR3C1 and hypertensive disorder: The deficiency of gestational proteins generates: hypomethylation of the Wnt2 promoter in the placenta associated with fetal growth alterations (141); decreased expression of IGF-I and IGF-II producing hyperglycemia (142); hypermethylation of the PPARγ and Glucocorticoid receptor (GR) promoters involved in the regulation of blood pressure and in the metabolism of lipids in adults (143); increased expression of angiotensin II which generates an increase in blood pressure (142) and decreased expression of the agtr1b gene involved in hypertension.