JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: Genomic instability is a hallmark of cancer, and high rates of genomic instability are present in other myeloid malignancies containing activated tyrosine kinase pathways, such as BCR/ABL in chronic myeloid leukemia, JAK2 in myeloproliferative neoplasias, and RAS mutations in myelodysplastic syndromes (45).