Verkerk et al. (23) described a family with members affected by TS and obsessive–compulsive disorder (OCD), in which mutations in CNTNAP2 gene expression have been found to alter the distribution of the K(+) channels in the nervous system with abnormal conduction and/or repolarization of active potential, leading to cause anomalous motor movements observed in individuals affected by TS. Here, CNTNAP2 is linked to Timothy syndrome.