The frequency BRAF aberrations in primary and metastatic tumors to the CNS (PA, pilocytic astrocytoma; PXA, pleomorphic xanthoastrocytoma; DA, diffuse astrocytoma; GBM, glioblastoma; GG/GC, ganglioglioma/gangliocytoma; DIA, desmoplastic infantile astrocytoma/ganglioglioma; DNET, dysembryoplastic neuroepithelial tumor; SEGA, subependymal giant cell astrocytoma; DLGNT, diffuse leptomeningeal glioneuronal tumor; LCH, Langerhans cell histiocytosis; MPNST, malignant peripheral nerve sheath tumor). The gene discussed is BRAF; the disease is Langerhans cell histiocytosis.