Previously, our team has analyzed the non-immunological role of B7-H3 in CRC tumorigenesis, which mainly focused on anti-apoptosis (29), pro-metastasis (30, 31), 5-Fu resistance (32, 33), and lipid metabolism (34); however, the relationship between B7-H3 and glucose metabolism was not investigated. The gene discussed is CD276; the disease is colorectal carcinoma.