Meningiomas with Krueppel-like-factor 4 (KLF4)/TNF receptor-associated factor 7 (TRAF7) mutation often locate in the medial skull base and v-akt murine thymoma viral oncogene homolog 1 (AKT1)/TRAF7 mutation in the anterior skull base (21). This evidence concerns the gene KLF4 and meningioma.