TP53 and breast cancer: For example, KDM5c was significantly upregulated in breast cancer tissues compared with paired normal breast tissues, and was positively correlated with metastasis (11); loss of KDM5c results in the activation of a set of enhancers in human breast cancer cells (12); KDM5c acts in proliferation and invasion of gastric cancer cells, which may be partly associated with p53 expression (13); and KDM5 demethylase suppresses STING-induced innate immune response in tumor cells (14, 15).