In conclusion, KDM5c promotes in vitro colon cancer cell growth by a mechanism involving demethylation of H3K4me3 in the TSS and downstream of the tumor suppressor gene FBXW7. H3K4me3 demethylation may recruit DNMT3b, resulting in methylation of the CpG island located near the TSS. Here, FBXW7 is linked to colonic neoplasm.