To assess KDM5c expression levels in colon cancer, we first analyzed the expression of KDM5c mRNA in 464 colon cancer tissues samples from a TCGA dataset (The Cancer Genome Atlas)4 and found that KDM5c expression was significantly increased in colon cancer tissue samples compared with normal tissue samples (Figure 7A). The gene discussed is KDM5C; the disease is colonic neoplasm.