The TCGA database DNA methylation analysis showed that higher methylation of FBXW7 DNA in colon cancer tissue correlated with high expression of KDM5c, (p < 0.05) but there was no association of JUN DNA methylation with KDM5c expression (p > 0.05) (Figure 6C). This evidence concerns the gene KDM5C and malignant colon neoplasm.