BTN3A1 is the main isoform of the butyrophilin 3A (BTN3A, CD277) family and can directly bind phosphor-antigens (62), activating the Vγ9Vδ2 T cells in colorectal cancer microenvironment for the anti-tumor response of zoledronate (63). Here, BTN3A1 is linked to colorectal cancer.