PDCD1 and hereditary sensory and autonomic neuropathy: A study analyzed the landscape of the immune cells in alveolar and found that proinflammatory subsets (central memory T cells, IL-1βhi populations) increased and the anti-inflammatory process was inhibited (decreased expression of CTLA-4 and PD-1 in T regulatory cells and decreased expression of counter-regulatory interleukin-1 receptor antagonist) in both T cells and myeloid cells in BALF, providing the possible underlying mechanisms of immune dysregulation in patients with CIP (58).