PDCD1 and melanoma: In another cohort containing 101 patients with unresectable stage III or IV melanoma treated with anti-PD-1 antibodies, the results showed that along with known prognostic factors, such as lactate dehydrogenase (LDH), PS score, and symptomatic brain metastasis, NLR was an independent prognostic factor for patient outcomes and was closely related to worse survival (39).