Moreover, many studies have reported that melanoma can continuously secrete chemokines such as interleukin-8 (IL-8), which upregulates the activity of β2 integrin on the surface of neutrophils, further promoting the binding between ICAM-1 on the surface of melanoma cells and β2 integrin on the surface of neutrophils (47–49). Here, ICAM1 is linked to melanoma.