Diagnostic performances of p16 immunostaining are considered high enough to diagnose a high-risk HPV infection in oropharyngeal squamous cells carcinomas, and according to the College of American Pathologists and to the eighth edition of the TNM classification, this assay can be used as a surrogate marker of high-risk HPV infection (24). Here, CDKN2A is linked to oropharynx squamous cell carcinoma.