TGFB1 and neoplasm: The mechanisms of tumor immune evasion include the reduction of antigen presentation due to the loss of major histocompatibility complex (MHC) class I expression, the production of immunosuppressive cytokines, such as interleukin (IL)-10 and transforming growth factor (TGF)-β, the resistance to apoptosis, and the expression of Fas ligand (FasL), which is capable of inducing the death of TILs (47).