TGFB1 and neoplasm: These tumor-promoting activities include the production of immunosuppressive cytokines IL-10 and TGF-β, the secretion of angiogenic factors, NO and reactive oxygen species (ROS), the promotion and activation of Tregs, and the induction of arginine and cysteine deprivation, which result in the metabolic suppression of tumor-infiltrating T cells and the production of soluble factors that support tumor growth and invasion (71, 77, 79, 80).