NLRP3 and melanoma: For instance, Nlrp3-deficient mice displayed reduced number of melanoma lung metastasis due to more active NK cells in a caspase-1-independent way, while in the context of colon metastasis to the liver, caspase-1 and NLRP3 were protective by promoting more active NK cells in the livers of WT mice compared with Caspase-1-deficient mice (17, 37).