Finally, cytokine measurement using multiplex technology of tumor supernatants at day 14 showed no difference in the amount of IL-1β, IL-33, CCL3/MIP1α, KC or β-FGF, between WT and Caspase-1 KO, while CCL5/RANTES was significantly increased in Caspase-1 KO (Supplementary Figure 3). Here, CALCA is linked to neoplasm.