Tumor cell suspensions from WT or Caspase-1 KO mice were incubated with a combination of IL-12+IL-18 cytokines, or with crosslinking antibodies against activating receptors (NKp46, Ly49D, NKG2D) or with different tumor cell lines (4T1, and YAC1 cells, a classical NK cell target). Here, IL18 is linked to neoplasm.