Similarly, the mRNA expression of EPAS1 cancer cells (KYSE70, KYSE450, and HKESC-1) is significantly higher (1.98 ± 0.09, 2.24 ± 0.11, 2.45 ± 0.12, respectively) than noncancerous HaCaT (1.2 ± 0.06) cells (Figure 3D). Here, EPAS1 is linked to cancer.