The ESCC cells with reduced EPAS1 expression (KYSE70−EPAS1 and KYSE150−EPAS1) cells showed significant (p < 0.01) reduction in wound healing, invasion, and migration capacity when compared with the control and nontransfected wild-type cancer cells (Figure 7). This evidence concerns the gene EPAS1 and esophageal squamous cell carcinoma.