EPAS1 and esophageal squamous cell carcinoma: On the other hand, the survival of patients with stage III ESCC having EPAS1 DNA amplification showed a significant reduction in patient survival compared to those of stages III patients with EPAS1 DNA deletion (873.79 ± 576.85 vs. 1,936.63 ± 622.19 days, p = 0.04) (Figure 4C).