EPAS1 and hereditary pheochromocytoma-paraganglioma: Dysregulation of EPAS1 is associated with the carcinogenesis of different types of cancers such as lung carcinoma (8), renal cell carcinoma (9), hepatocellular carcinoma (10), neuroblastoma (11), pheochromocytoma (12), glioma (13), and colorectal adenocarcinoma (14).