Patients with ESCC having EPAS1 DNA number amplification showed short survival when compared with that of EPAS1 DNA deletion (1,568.62 ± 515.31 vs. 2,239.18 ± 489.48 days; p = 0.2), although the difference in survival time between the groups did not reach statistical significance (Figure 4B). Here, EPAS1 is linked to esophageal squamous cell carcinoma.