Accordingly, it was reported that expression of EPAS1 is associated with pathogenesis, progression, and prognosis of different cancers, including non–small cell lung carcinoma (8), renal cell carcinoma (9), hepatocellular carcinoma (10), neuroblastoma (11), pheochromocytoma (12), glioma (13), and colorectal carcinoma (14). Here, EPAS1 is linked to hereditary clear cell renal cell carcinoma.