Tumor-promoting oncogenic roles of EPAS1 was noted in the pathogenesis of lung carcinoma, renal cell carcinoma, liver neuroblastoma, pheochromocytoma, and so on (8–12), whereas other studies reported the tumor-suppressive properties in the pathogenesis of glioma, colorectal carcinoma, and neuroblastoma (13, 14, 38). This evidence concerns the gene EPAS1 and hereditary pheochromocytoma-paraganglioma.