P-selectin on activated platelets interacting with tumor cells mediate their adhesion to endothelial cells and P-selectin−/− mice or platelets support significantly less lung metastasis (83, 145, 165, 166), although infusion of P-selectin+/+ platelets after tumor cell injection partially recovers metastatic nodules, suggesting that platelet P-selectin acts as a pro-metastatic adhesion molecule to both endothelial and tumor cells (167). Here, SELP is linked to neoplasm.