Pro-inflammatory cytokines [i.e., TNF-α and interleukin (IL)-1β] and pro-angiogenic factors (i.e., VEGF) released by tumor cells induce the overexpression of TF by endothelial cells and monocytes (123–128) and the release of vWF by endothelial cells (129). The gene discussed is VWF; the disease is neoplasm.