In addition, the amounts of IFN-γ and IL-2 were lower in α19BBZ-LRP6 CAR-T cells than that in α19BBZ CAR-T cells after stimulation by the tumor cells (Figures 3C,D), which suggests that the α19BBZ-LRP6 T cells may have a lower risk of developing cytokine-releasing syndrome. Here, LRP6 is linked to neoplasm.