Another study reported a role of IRF4 in the regulation of pathological cardiac hypertrophy, which mediated by cyclic adenosine monophosphate (cAMP) response element‐binding protein (CREB).[45] Moreover, CREB/cAMP in skeletal muscle can regulate exercise performance and glycogen content.[46] These studies suggested that IRF4 may regulate glycogen through CREB. Here, CREB1 is linked to cardiac hypertrophy.