ITGB4 and neoplasm: These include DNA, RNA (e.g., messenger RNA (mRNA), microRNA, and long non‐coding RNA) and proteins (e.g., ligands and receptors), which have been associated with development, immune response, neurodegenerative diseases, developmental disorders, and cancer progression.[3, 6, 7, 8, 9, 10, 11] Tumor exosomes have been shown to be organotropic in facilitating subsequent metastasis to the tropic organs.[12] Specific integrins (ITGs) have been found to redirect tumor exosomes to the lungs (ITGβ4) and liver (ITGβ5).