HLA-C and cancer: This led to the identification of 11 T cell subsets with corresponding signature genes.[70] The ability to examine TCR sequences by RNA‐seq on a single cell basis is particularly important since TCRs are used to identify different T cell lineages, recognize the antigen presented by MHC, and control T cell activation.[107] Identification of distinct features of T cell populations can therefore give insight and guidance into designing powerful ACT for cancer immunotherapy.