Cyanosis is a blue color throughout the skin and mucous membranes due to reduced hemoglobin in the blood, which could be caused by multiple conditions including heart disease, respiration failure, and extreme hypoglycemia.[12] Generally, cyanosis and death caused by respiration failure would occur within 2 h after birth,[13] but this timeline did not match our observations where Cavin1−/− mice survived ≈10 h after birth (Figure 1B). This evidence concerns the gene CAVIN1 and Abnormality of the skin.