CAVIN1 and congenital generalized lipodystrophy type 4: Congenital generalized lipodystrophy type 4 (CGL4) is a rare disease caused by mutations in the gene CAVIN1, also known as polymerase I and transcript release factor, with systemic loss of body fat and predisposition for diabetes mellitus, hypertriglyceridemia, and hepatic steatosis.[1, 2]