FOXO1 and lumbar disk degenerative disorder: Moreover, it was observed that SIRT1 could alleviate oxidative stress‐induced senescence of CEP cells by inhibiting the p53/p21 pathway.[89] Sparstolonin B was shown to be capable of preventing lumbar intervertebral disc degeneration (IVDD)‐induced oxidative stress, inflammation and apoptosis through NADPH oxidase activation, TLR4/MyD88/NF‐κB and the phosphoinositide 3‐kinase/protein kinase B signaling pathway.[90] Forkhead box O1 (FoxO1) plays a pivotal role in preventing physiological oxidative damage in the bone.