In Cohort II, where variant histology had been denoted upon re-evaluation of the tumours, LY6D expression was found to be higher in tumours with squamous differentiation and lower in tumours with other variant histologies, e.g. nested, micropapillary, microcystic, glandular, sarcomatoid or giant cell, compared to classic urothelial tumours. Here, LY6D is linked to neoplasm.