Not only that, our further study demonstrated that there was a synergistic effect of inhibiting invasion if both LAMP2 and ERBB2 were down-regulated in TSTA3 overexpressed KYSE150 cells (Figure 7F-G). Down-regulation of LAMP2 or ERBB2 alone may affect cell growth, proliferation, and cell death in ESCC (Figure S9). This evidence concerns the gene GFUS and esophageal squamous cell carcinoma.